Name: Creamy Spinach Artichoke Chicken Casserole Recipe
Prep time: 15 min
Cook time: 30 min
Total time: 45 min
Cuisine: American
Ingredients: 8 ounces cream cheese (at room temperature); 1 cup plain Greek yogurt (or sour cream); 1 cup shredded mozzarella cheese, divided; ⅓ cup grated Parmesan cheese, plus more for topping; 1 clove garlic, minced; 3 cups artichoke hearts, roughly chopped (frozen and defrosted, or canned and drained); 1 (5-ounce) bag baby spinach; 2 heaping cups cooked chicken; ½ teaspoon kosher salt; ¼ teaspoon freshly cracked black pepper; Avocado oil or cooking spray (for greasing the baking dish)

Jump to Recipe· 4.2 from 40 reviews

If you’re craving a dish that wraps up the lusciousness of spinach and artichokes with tender chicken and an irresistible cheesy embrace, then this Creamy Spinach Artichoke Chicken Casserole Recipe is about to become your new best friend in the kitchen. It’s the kind of meal that feels like a warm hug on a plate, packed with gooey cheese, savory bites of chicken, and plenty of vibrant greens—all baked together to create layers of comforting flavor. Whether you’re feeding a hungry family or want an easy, crowd-pleasing dinner, this casserole strikes the perfect balance between rich and wholesome, bringing a fresh twist to classic favorites.

Ingredients You’ll Need

A round silver mixing bowl sits on a white marbled surface, held by two woman's hands on opposite sides. Inside the bowl, four layers are clearly visible: a creamy white layer of cream cheese or similar spread sits at the bottom, topped on the left side with a layer of small, light beige pieces that look like chopped cooked chicken. On the top right, there is a roughly chopped pale green layer of artichoke hearts. At the bottom right, fresh dark green spinach leaves rest loosely. The layers create a simple mix of colors and textures, ready to be stirred. photo taken with an iphone --ar 4:5 --v 7

The beauty of this casserole lies in its simple, wholesome ingredients that each play a crucial role. From the creamy base to the fresh veggies and flavorful cheeses, every element contributes to creating a dish that’s both satisfying and hearty.

Cream cheese (8 ounces): Adds that signature creamy texture that makes this casserole irresistibly smooth.
Plain Greek yogurt (1 cup): Brings tanginess and lightness, perfect for balancing the richness of the cheese.
Shredded mozzarella cheese (1 cup, divided): Melts beautifully, creating that lovely gooey top everyone loves.
Grated Parmesan cheese (⅓ cup plus more for topping): Delivers a sharp, salty bite that lifts the overall flavor.
Garlic (1 clove, minced): Infuses a subtle aromatic punch that’s essential for depth.
Kosher salt (½ teaspoon): Enhances all the other ingredients without overwhelming them.
Freshly cracked black pepper (¼ teaspoon): Adds a mild heat that rounds out the taste.
Artichoke hearts (3 cups, chopped): Bring a delightful tangy bite and tender texture; use thawed frozen or canned and drained.
Baby spinach (1 bag, 5 ounces): Offers vibrant color, nutrients, and a gentle earthiness to brighten every forkful.
Cooked chicken (2 heaping cups): The hearty base protein that makes the casserole a well-rounded meal.

How to Make Creamy Spinach Artichoke Chicken Casserole Recipe

Step 1: Prepare the Oven and Creamy Base

Start by preheating your oven to 375°F. While it warms, combine the cream cheese, Greek yogurt, half of the mozzarella cheese, Parmesan, garlic, salt, and pepper in a mixing bowl. Using a stand mixer with a paddle attachment is ideal here because it’ll whip these ingredients into a luxuriously smooth and creamy base. Don’t have a stand mixer? No worries! A hand mixer or even a sturdy wooden spoon can do the trick—just make sure your cream cheese is at room temperature so mixing is easier and the texture stays silky.

Step 2: Fold in the Vegetables and Chicken

After your creamy mixture is well combined, it’s time to add in the star veggies and protein. Gently stir in the roughly chopped artichoke hearts, fresh baby spinach, and the cooked chicken. This combination brings a fantastic mix of textures and flavors that meld beautifully during baking. Make sure everything is evenly incorporated—a uniform mixture ensures every scoop is packed with goodness.

Step 3: Assemble the Casserole

Grab a 9×13-inch ceramic or glass baking dish and lightly spray it with avocado oil or your favorite cooking spray to prevent sticking. Transfer the creamy chicken and veggie mix into the dish, spreading it out evenly to create a flat surface. Then sprinkle the remaining mozzarella and a bit more Parmesan on top to set the stage for that golden, bubbly crust.

Step 4: Bake to Perfection

Cover your casserole loosely with foil and pop it into the oven. Bake for 20 minutes to let the flavors meld and the inside warm through. After that, remove the foil and bake uncovered for an additional 5 to 10 minutes. This final step allows the cheese on top to bubble and develop a gorgeous golden crust that’s both visually appealing and delicious.

Step 5: Let It Rest Before Serving

Once out of the oven, be patient and let the casserole cool for about 10 to 15 minutes. This resting time helps the casserole set, making it easier to slice and serve without losing that creamy texture. Plus, it gives the flavors a chance to deepen, so every bite is pure comfort.

How to Serve Creamy Spinach Artichoke Chicken Casserole Recipe

A white baking dish filled with a creamy, cheesy casserole dish featuring three visible layers: the top layer is golden-brown melted cheese with some darker toasted spots, below it is a thick white sauce with melted cheese strings stretching as a serving spoon lifts a portion, and the bottom layer contains chunks of artichoke hearts mixed with creamy sauce. The edges of the dish show some baked-on brown spots. The background is a white marbled surface. Photo taken with an iphone --ar 4:5 --v 7

Garnishes

To make your Creamy Spinach Artichoke Chicken Casserole Recipe pop even more, consider scattering some freshly chopped parsley or basil on top just before serving. A sprinkle of extra grated Parmesan adds a nice visual contrast and an extra cheesy hit for those who can’t get enough indulgence. For a little zing, a light drizzle of lemon juice or a few red pepper flakes can awaken the flavors beautifully.

Side Dishes

This casserole is a hearty main dish, but pairing it with some simple sides can round out your meal perfectly. A crisp green salad dressed with a tangy vinaigrette can cut through the richness. Roasted vegetables, such as asparagus or broccoli, complement the creamy texture with their natural char and crunch. If you’re feeling cozy, some warm crusty bread or garlic rolls are always a crowd-pleaser.

Creative Ways to Present

To elevate the presentation, bake the casserole in colorful individual ramekins instead of a single dish. This not only looks charming but also makes portioning effortless. Alternatively, try layering the mixture with thinly sliced potatoes or even some cooked pasta for a hearty twist. Serve with a sprinkle of toasted pine nuts or breadcrumbs for added texture and a touch of sophistication.

Make Ahead and Storage

Storing Leftovers

After enjoying your Creamy Spinach Artichoke Chicken Casserole Recipe, store any leftovers in an airtight container and keep them in the refrigerator for up to 3 days. The flavors continue to develop as it sits, making your next meal just as delicious. Simply cover and chill, making sure to cool it completely before sealing to maintain freshness.

Freezing

This casserole freezes beautifully! For the best results, assemble it but don’t bake initially—wrap it tightly with plastic wrap and foil to prevent freezer burn, then freeze for up to 2 months. When you’re ready to eat, thaw overnight in the refrigerator and bake as directed, adding a few extra minutes if baked straight from the freezer.

Reheating

To bring leftovers back to life, reheat them in the oven at 350°F for about 15-20 minutes, covered with foil to prevent drying out. For a quicker option, microwave individual portions on medium power in short intervals, stirring occasionally to heat evenly. Either way, you’ll enjoy that rich, creamy goodness every time.

FAQs

Can I use fresh artichokes instead of canned or frozen?

Absolutely! Fresh artichokes work wonderfully but require a bit more prep—cleaning, trimming, and boiling until tender before chopping. If you have the time, fresh will add an earthy flavor that’s delightful in this casserole.

Is it possible to make this recipe dairy-free?

While this casserole relies heavily on dairy for its creamy texture, you can use dairy-free cream cheese, yogurt alternatives, and vegan cheeses. The texture and taste may vary slightly, but it’s a workable option for those with dietary restrictions.

Can I substitute the chicken with another protein?

Definitely! Shredded turkey or cooked chopped sausage would be tasty swaps. Even hearty vegetables like mushrooms or roasted cauliflower can turn this into a vegetarian delight if you omit the meat.

How spicy is this casserole?

This recipe is mild by nature, focusing on creamy and cheesy flavors. If you want to add a bit of heat, consider adding a pinch of crushed red pepper flakes to the mixture or sprinkling them on top before baking.

What’s the best way to ensure the casserole isn’t watery?

Make sure your spinach is well drained or sautéed to remove excess moisture before mixing. Also, picking canned artichokes that are well drained helps keep the casserole from becoming soggy.

Final Thoughts

I hope you’re as excited as I am to dive into this Creamy Spinach Artichoke Chicken Casserole Recipe. It’s truly one of those dishes that feels like home in every bite—a seamless combination of comfort and freshness that’s perfect for busy weeknights or special family dinners. Give this recipe a try, and you might just find your new go-to crowd-pleaser that gets requested again and again!